Curriculum vitae

Extensive experience in Bioinformatics, scientific instrumentation, statistical data analysis, signal and image processing, and computer science. Skilled in leading multiple projects and multi-disciplinary research teams. An experienced software engineer with a PhD in theoretical chemistry. Has developed complex software in support of leading-edge medical and bioinformatics technologies.

In 1995, OGS embarked on the development the world's first large scale automated Proteomics factory, using electrophoresis of 2D gels and mass spectrometry to identify proteins of biological and pharmaceutical significance. I was appointed Director of Bioinformatics and my responsibilities included:

• The architecture and management of the software infrastructure in support of these new processes, including the Laboratory Information Management System, imaging and mass spectrometry data capture and analysis, and development of statistical and visualisation methods for end-user interrogation of the integrated data.
• Development of alliances with key academic groups and specialised software contractors, and management of collaborative development and research projects, including:

  Specialised LIMS system for Proteomics, with the bioinformatics consultancy firm, Pangea Systems

  Customisation of the Melanie image analysis software, with Ron Appel, University of Geneva

  Development of improved image analysis algorithms, with Roland Wilson, University of Warwick

  Integration of Sequest software by Jimmy Eng and John Yates for tandem spectrum interpretation, with Ruedi Aebersold, University of Washington

  Isotopic peak deconvolution in MALDI spectra, with John Skilling, MaxEnt Solutions

  Integration of Mowse mass-matching software, with Darryl Pappin, ICRF

OGS now has extensive and fully operational facilities in Oxfordshire supported by this system.

By 2001, I was directing a team of 12, comprising software developers, data analysts and bioinformaticians. Responsibilities of the team included:

• Development, delivery and support of novel Proteomics databases and data mining applications for major pharmaceutical company customers and internal target discovery research
• Development of image processing software in support of in-house Proteomics operations
• Improved Bayesian scoring statistics to increase sensitivity of protein mass spectral interpretation
• Bioinformatics research for new product development

On joining OGS, I developed instrumentation and software for the analysis of carbohydrates, becoming head of the software team of 3 in 1991. My own main projects were:

• Design and implementation of a real-time embedded operating system for custom-built 68000-based instrument controllers, used by OGS for all its instrument products.
• Calibration of LC systems for size and charge separation of carbohydrates, and structural interpretation of the elution times of chromatographic peaks
• Design of a feedback optimising system to determine the most efficient experimental strategy in parallel and sequential sequencing reactions.
• Design and implementation of carbohydrate sequencing analysis software application (EVE) which coupled the biological modelling of in-vivo glycoprotein synthesis with the modelling of rules for exo-glycosidase specificity to deduce the sequence of carbohydrates analysed with the OGS RAAM Glycosequencer instruments.

• Support and development of an assembler implementation of the Prolog language running under DOS, and a C implementation under UNIX
• Management of a network of workstations
• Development of a graphical debugging system for the Prolog language

• Implemented all aspects of computer control, data acquisition, Fourier analysis, data processing, graphical display and user interface for the world's first high field Magnetic Resonance Imaging instruments.
• Worked closely with electronics engineers and NMR scientists to design interfaces and protocols for instrument control and data analysis.
• Designed and implemented a 3D image display and processing system.